Combining systems biology with cheminformatics, I hope to develop new discovery platforms to quickly find new disease therapies.
Currently, I'm focussed on finding new therapies against Tuberculosis, a disease that kills 1.5 million people per year.
Evolution of pathogenic bacteria in response to drug treatment and the transmissibility of resistance genotypes exhausts the antimicrobial discovery pipeline, causing an unsustainable cycle of drug discovery followed by global resistance. I envision physicians curing infections using personalized, rational, and narrow spectrum combination therapies specifically selected to prevent resistance and minimize patient side effects.
My research interests therefore lie in pursing the answers to these questions:
My broad skills and experience in chemistry, biochemistry, microbiology, and computational biology will be synthesized to harness a holistic chemical genetic paradigm of data-driven systems chemical biology to answer these questions.
Chemical biology, quantitative biology and their intersection for therapeutics discovery.
New inhibitors of Mycobacterium tuberculosis identified using systems chemical biology
bioRxiv, Aug 2018, 140(7), 2514-2527
A Structural Model of a P450-Ferredoxin Complex from Orientation-Selective Double Electron-Electron Resonance Spectroscopy
Journal of the American Chemical Society, Feb 2018, 140(7), 2514-2527
Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1)
Catalysis Science and Technology, Sep 2018, 6(20), 7549-7560
Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity
Chemical Communications, Dec 2012, 48(95), 11692-11694
Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation
Biochemical Journal, Nov 2012, 448(1), 55-65
The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Dalton Transactions, Jul 2012, 41(28), 8703-8714
Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2
Molecular BioSystems, Jan 2010, 6(1), 206-214
Protein recognition in ferredoxin-P450 electron transfer in the class I CYP199A2 system from Rhodopseudomonas palustris
Journal of Biological Inorganic Chemistry, Mar 2010, 15(3), 315-28
Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris
Proteins, Dec 2009, 77(4), 867-880